Association between circulating furin levels, obesity and pro?inflammatory markers in children

Aim To, in children, investigate the associations between serum furin, obesity, overweight, body fat and circulating markers reflecting adipose tissue or systemic inflammation. Methods We analysed leptin, adipocyte fatty acid–binding protein, triglycerides, interleukin (IL)-6, IL-8 C-reactive protein from 166 children Pediatric Osteoporosis Prevention (POP) study collected at mean age (SD) 9.9 (0.6) years. Children were classified as low-to-normal weight, overweight obese. Total mass (kg), trunk (kg) total lean measured by dual-energy X-ray absorptiometry. Body percentage (%) was calculated. Results found that furin levels higher with obesity compared weight (p < 0.001 p = 0.006, respectively). Also, there positive correlations mass, percentage, adipokines pro-inflammatory markers. Conclusion This indicates adiposity a milieu children. suggest future studies role of inflammation associated increased risk cardiometabolic diseases Studies should also whether could be link severe coronavirus disease 2019